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TESTOSTERONE

Testosterone belongs to a class of hormones called androgens. Testosterone affects sexual desire, sexual satisfaction, mood, energy level, bone health and muscle mass and strength. Testosterone is produced by the ovaries, the adrenal glands and in peripheral tissues. Women produce much less testosterone than men.

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There is no dramatic change in testosterone level at natural menopause but a gradual decline with aging. There are exceptions to this such as women who have their ovaries surgically removed or have induced menopause. They often experience a sharper drop in their level of testosterone.

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Some studies in menopausal women with low sexual desire show that testosterone treatment (delivered by skin patch, topical gel or spray, or subcutaneous pellet) can boost sexual interest and activity. . Although short-term treatment (for about 6 months) appears to be safe, we don’t yet know about long-term safety, especially with regard to breast cancer or heart disease. Studies are ongoing, but results may not be available for several years.

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There is currently no form of testosterone approved by the FDA for use in women. 

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Prescription testosterone products developed for men, such as Androderm, Testoderm, and Androgel, can be prescribed off-label for women at approximately 1/10th the daily dose that is prescribed for men.

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Custom-compounded testosterone is also available through prescription; however, compounded medications have quality and safety concerns.

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There are many uncertainties about the role of androgens in female health,  and while the risks and side effects are rare if the level is kept within the female normal range, high doses may cause side effects. Further study is needed to determine the effectiveness and safety of long-term androgen use by women.

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